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KMID : 0605619990060010125
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Journal of Korean Society of Biological Psychiatry
1999 Volume.6 No. 1 p.125 ~ p.134
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Negative Association between Schizophrenia and Rheumatoid Arthritis : Epidemiology and Prolactin and Estrogen as Protective Factors
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1안동성/1Dong Sung Ahn
2이영호/3이윤우/2Young Ho Lee/3Yoon Woo Lee
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Abstract
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The purposes of this study were to test the negative association between
schizophrenia and rheumatoid arthritis(RA) and to clarify the role of prolactin and
estrogen as protective factors in this association.
The author compared the prevalence rate of RA between 561 patients with
schizophrenia and 222 patients with mood disorder. For investigating the role of estrogen
and prolactin, the author checked the plasma prolactin and estradiol level in 80 patients
with paranoid schizophrenia and 77 patients with RA.
The results were as follows.
1) Epidemiological data
The prevalence rate of RA in the schizophrenic group was 0/561 and that of RA in
the mood disorder group was 2/222. To compare these results between two groups, the
author applied the Binomial test using the average prevalence rate of RA(0.8%) in the
general population as a reference rate. The prevalence rate of RA in the schizophrenic
group was significantly lower than that of RA in the general population. However, the
prevalence rate of RA in the mood disorder group was not significantly different to that
of RA in the general population.
2) Comparison of plasma prolactin and estradiol level between two groups.
The plasma level of prolactin in the schizophrenic group was significantly higher than
that of prolactin in th RA group(p=0.000). However, the plasma level of estradiol in the
schizophrenic group was significantly lower than that of estradiol in the RA
group(p=0.017). These results were not consistent across gender. To contrast with the
results in the female group, which were consistent with the results in the total subjects,
for the male group, the plasma levels of prolactin and estradiol in the schizophrenic
group were significantly higher than those of prolactin and estradiol in th RA group.
These results support the results of previous studies which confirm the negative
association between schizophrenia and RA. These results also suggest that the elevation
of plasma prolactin level in the patient with schizophrenia has a antirheumatic effect
while the elevation of plasma estradiol level in the patients with RA has a
anti-schizophrenic effect, and that these effects act as a possible mechanism in the
negative association between two disorders. However, these results suggest that this
association is specific to female patients.
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KEYWORD
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